what is the standard normal table for z score 3.656

As the folded protein structures are tightly packed and surrounded by solvent molecules, the surrounding circumstances of interacting atoms are inhomogeneous and anisotropic. Typical pairwise potentials cannot accurately describe non-bonded interactions in protein structures. The key idea in the development of statistical potentials is how to decompose the 3-D network of interactions in protein structures. Although their physical interpretations are still debated, due to their accuracy and computational efficiency, statistical potentials have been used with considerable success in many applications such as fold recognition and threading, protein structure prediction, protein design, binding and aggregation. Any aspect of structural features which characterize important interactions in the folded structures can be incorporated into the derivation of statistical potentials.

Such energy functions, called statistical potentials or knowledge-based potentials are derived by converting the observed frequencies of residue or atomic interactions in a database of protein structures into the free energies of corresponding interactions. One approach for the design and construction of potential energy functions is to make use of the information embedded in the known protein structures. Understanding the structure and function of proteins requires an accurate potential energy function to quantify interactions between residues or atoms. The results show that ROTAS performs better than other competing potentials not only in native structure recognition, but also in best model selection and correlation coefficients between energy and model quality. The performance of ROTAS was tested using 13 sets of decoys and was compared to those of existing atomic-level statistical potentials which incorporate orientation-dependent energy terms. Such rotamer-dependencies are not limited to specific type or certain range of interactions. It was clearly found that the rotameric state is correlated to the specificity of atomic interactions. In this potential, named “rotamer-dependent atomic statistical potential” (ROTAS), the interaction between two atoms is specified by not only the distance and relative orientation but also by two state parameters concerning the rotameric state of the residues to which the interacting atoms belong.

In this study, we develop a new multibody statistical potential which can account for the influence of rotameric states on the specificity of atomic interactions.

What is the standard normal table for z score 3.656